Endocrine Abstracts

Introduction: ACTH-secreting macroadenomas account for about 4–10% of Cushing’s disease and are often resistant to surgical treatment and radiotherapy. The aim of the study was to present diagnostic and therapeutic difficulties in a case of cyclic recurrent ACTH-dependent Cushing’s syndrome due to atypical pituitary adenoma.Case report: 50-year-old man with visceral obesity was referred to hospital because of poor control of diabetes and h...

Introduction: Insulinoma is a rare form of a functional neuroendocrine tumor with an estimated incidence at 1–2 new cases per million persons per year. This infrequent endocrinopathy, frequently escaping standard disease course, constitutes a diagnostic challenge for every endocrinologist. Successful surgical resection of the lesion is the only available method that ensures patient’s full recovery.Case study: 53 years old patient with complaint...

Introduction: Immunoglobulin-G4-related disease (IgG4RD) is a multidisciplinary problem due to plasmatic cells infiltration and areas of fibrosis in the affected tissues. In IgG4RD, elevation of serum IgG4 immunoglobulins is present. Clinically, the disease is mainly manifested as: autoimmune pancreatitis, salivary gland involvement, sclerosing cholangitis, lymphadenopathy, lachrymal gland enlargement, retroperitoneal fibrosis or orbital pseudotumor. The simultaneous involveme...

Introduction: Hypopituitarism is characterized by the absence of pituitary hormones. Depending on what pituitary hormones are missing and what is the etiology of hypopituitarism, its clinical manifestation varies. Apart from evident symptoms and signs of hypopituitarism due to hormonal insufficiencies, several studies reveal that long-standing hypopituitarism, including particularly absence of GH, is related to higher risk of metabolic syndrome.Objective...

Introduction: The admission glucose may be a predictor of survival and is independently associated with infarct size and higher mortality in patients with ACS. Hyper-homocysteinemia in patients with ischaemic heart disease represents a strong predictor of vascular morbidity. The role of glucose increase above normal levels in non-diabetic patients with ACS is not adequately defined. The aim was the assessment of dependence between admission blood glucose and homocysteine conce...

Introduction: Pituitary gland, sella turcica and parasellar region can be involved by wide variety of lesions. Diagnosis of this pathology demands a multidisciplinary effort, especially endocrinological, ophthalmologic and neurological procedures. Each of these entities has unique diagnostic and treatment considerations.Aim: Review of clinical symptoms related to sellar–parasellar region tumors and documentation of heterogeneity of clinical syndrome...

Introduction: Hypopituitarism can be caused by a number of different etiologic factors including metastatic cancer. Metastasis to the pituitary gland is rare, accounting for only 1.8% of all metastases, and is often detected incidentally by symptoms associated with hormone dysfunction like hyponatremia. Breast and lung cancer are the primary neoplasms with well established properties of pituitary infiltration. Metastases from gastric cancer are unusual and constitute less than...